Vanoxerine

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Vanoxerine
Vanoxerine.png
Vanoxerine ball-and-stick.png
Systematic (IUPAC) name
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
Clinical data
Legal status
  • Investigational New Medicine
Pharmacokinetic data
Biological half-life 6 hours approx
Identifiers
CAS Number 67469-78-7 N
ATC code none
PubChem CID: 3455
ChemSpider 3337 YesY
UNII 90X28IKH43 YesY
ChEMBL CHEMBL281594 YesY
Chemical data
Formula C28H32F2N2O
Molecular mass 450.563 g/mol (freebase); 523.494 g/mol (dihydrochloride)
  • Fc1ccc(cc1)C(OCCN2CCN(CC2)CCCc3ccccc3)c4ccc(F)cc4
  • InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 YesY
  • Key:NAUWTFJOPJWYOT-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Vanoxerine (GBR-12909) is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor (DRI). GBR-12909 binds to the target site on the dopamine transporter (DAT) ~ 50 times more strongly than cocaine,[1] but simultaneously inhibits the release of dopamine. This combined effect only slightly elevates dopamine levels, giving vanoxerine only mild stimulant effects.[2] Vanoxerine has also been observed to be a potent blocker of the IKr (hERG) channel.[3]

Vanoxerine as a treatment for cocaine dependence

Vanoxerine has been researched for use in treating cocaine dependence both as a substitute for cocaine and to block the rewarding effects. This strategy of using a competing agonist with a longer half-life has been successfully used to treat addiction to opiates such as heroin by substituting with methadone. It was hoped that vanoxerine would be of similar use in treating cocaine addiction.[4][5]

Research also indicates that vanoxerine may have additional mechanisms of action including antagonist action at nicotinic acetylcholine receptors,[6] and it has also been shown to reduce the consumption of alcohol in animal models of alcohol abuse.[7]

Vanoxerine has been through human trials up to Phase II,[8][9][10] but development was stopped due to observed QTc effects in the context of cocaine use.[11]

However, GBR 12909 analogs continue to be studied as treatments for cocaine addiction.[12][13] As an example, GBR compounds are piperazine based and contain a proximal and a distal nitrogen. It was found that piperidine analogs are still fully active DRIs, although they do not have any affinity for the "piperazine binding site" unlike the GBR compounds. Further SAR revealed that while there are 4 atoms connecting the two fluorophenyl rings to the piperazine, the ether in the chain could be omitted in exchange for a tertiary nitrogen. Vanoxerine, a blocker of the dopamine carrier devoid of action on the noradrenaline carrier, while fully increasing dopamine in the nucleus accumbens, is ineffective in raising extracellular dopamine in the prefrontal cortex.[citation needed]

Vanoxerine as an antiarrhythmic

Vanoxerine is a drug currently in phase IIb human trials for its use as an antiarrhythmic.[14] It was previously indicated as a treatment for Parkinson’s disease and depression; however, it had no significant benefit with these diseases.[15] Vanoxerine is now being investigated for its potential benefits in treating cardiac arrhythmias.

Medical uses

Vanoxerine is a potentially effective treatment for abnormal heart rhythms. A significant cause of abnormal heart rhythms is reentry, an electrophysiologic event in which the proliferating signal refuses to terminate, and endures to reexcite the heart after the refractory period.[16]

It is likely that vanoxerine acts to prevent reentrant circuits. Vanoxerine terminates atrial flutters and atrial fibrillations (both cardiac abnormal heart rhythms) by blocking the recirculating electrical signal, and preventing the reformation of the reentrant circuit.[17] Vanoxerine has also shown a tendency to reduce the recurrence of cardiac arrhythmias, as it was exceedingly difficult to reproduce an atrial flutter or fibrillation in a subject that had been taking vanoxerine.[3]

Experiments have successfully been performed on cell cultures, canine hosts, and testing has moved towards human trials.

In clinical human trials with increasing dosages, vanoxerine has shown to have a highly favourable therapeutic index, showing no side effects at concentrations much higher than the therapeutic dose.[3] In canines, the effective therapeutic dose was between 76 ng/ml and 99 ng/ml, however the drug reached plasma concentrations of 550 ng/ml without harmful side effects, presenting a desirable therapeutic index.[3]

One of the major benefits of vanoxerine is that it does not appear to cause the same harmful side effects as its most comparable contender, amiodarone.[15]

Cellular mechanism

At a cellular level, vanoxerine acts to block cardiac ion channels.[15] Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels.[15] By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine.[15]

Molecular mechanism

At this time, little is known about the molecular mechanism of vanoxerine, and steps are being made towards understanding how vanoxerine operates on a molecular level.

See also

References

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  15. ↑ 15.0 15.1 15.2 15.3 15.4 Lua error in package.lua at line 80: module 'strict' not found.
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