Dopexamine

Dopexamine

Systematic (IUPAC) name
4-[2-({6-[(2-phenylethyl)amino]hexyl}amino)ethyl]benzene-1,2-diol
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	86197-47-9 Y
ATC code	C01CA14 (WHO)
PubChem	CID: 55483
ChemSpider	50102 Y
UNII	398E7Z7JB5 Y
KEGG	D03891 Y
ChEMBL	CHEMBL77622 Y
Chemical data
Formula	C22H32N2O2
Molecular mass	429.43 g/mol
SMILES Oc1ccc(cc1O)CCNCCCCCCNCCc2ccccc2
InChI InChI=1S/C22H32N2O2/c25-21-11-10-20(18-22(21)26)13-17-24-15-7-2-1-6-14-23-16-12-19-8-4-3-5-9-19/h3-5,8-11,18,23-26H,1-2,6-7,12-17H2 Y Key:RYBJORHCUPVNMB-UHFFFAOYSA-N Y
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Dopexamine is a synthetic analogue of dopamine. Despite this, it is a β₁ and β₂ adrenoreceptor agonist. Its agonism of peripheral D₁ dopamine receptors mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D₂ receptors decreases norepinephrine (noradrenaline) release.

Use in sepsis has been proposed.

It is used as an inotropic agent in cardiac failure. Side effects include arrhythmia, tremor, angina and flushing.