Propylnorapomorphine

Propylnorapomorphine

Systematic (IUPAC) name
(6aS)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
Clinical data
Legal status	Uncontrolled
Routes of administration	Oral
Identifiers
CAS Number	57559-68-9
ATC code	none
PubChem	CID: 5311191
ChemSpider	4470712
Chemical data
Formula	C19H21NO2
Molecular mass	295.38 g/mol
SMILES CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O

N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine. In rodents it has been shown to produce hyperactivity, stereotypy, hypothermia, antinociception, and penile erection, among other effects. Notably, its effects on locomotion are biphasic, with low doses producing inhibition and catalepsy and high doses resulting in enhancement of activity. This is likely due to preferential activation of D₂/D₃ autoreceptors versus postsynaptic receptors, the latter of which overcomes the former to increase postsynaptic dopaminergic signaling only with high doses.

See also

• Apomorphine