Sumanirole

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
Sumanirole
File:Suminarole.png
Systematic (IUPAC) name
(R)-5,6-dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one
Identifiers
CAS Number 179386-43-7
179386-44-8 (maleate)
ATC code none
PubChem CID: 9818479
IUPHAR/BPS 3949
ChemSpider 7994229
UNII 3E93IV1U45 YesY
ChEMBL CHEMBL419792
Chemical data
Formula C11H13N3O
Molecular mass 203.240 g/mol
  • CNC3Cn1c2c(C3)cccc2nc1=O

Sumanirole (PNU-95,666) is a highly selective D2 receptor full agonist, the first of its kind to be discovered.[1][2][3] It was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use [4][5] it is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action. [3]

See also

References

<templatestyles src="Reflist/styles.css" />

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />


  1. ↑ Romero AG, et al. Synthesis of the selective D2 receptor agonist PNU-95666E from D-phenylalanine using a sequential oxidative cyclization strategy. Journal of Organic Chemistry. 1997; 62(19):6582.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
Retrieved from "https://infogalactic.com/w/index.php?title=Sumanirole&oldid=5200112"