Chlorisondamine

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Chlorisondamine
Chlorisondamine.png
Systematic (IUPAC) name
trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-isoindolin-2-ium-2-yl)ethyl]ammonium dichloride
Identifiers
CAS Number 7701-62-4 YesY
ATC code none
PubChem CID: 6244
ChemSpider 6008 YesY
UNII JD3M24F66I YesY
ChEMBL CHEMBL2104531
Chemical data
Formula C14H20Cl6N2
Molecular mass 429.04 g/mol
  • [Cl-].[Cl-].Clc1c2c(c(Cl)c(Cl)c1Cl)C[N+](C2)(C)CC[N+](C)(C)C
  • InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2 YesY
  • Key:IXWDUZLHWJKVPX-UHFFFAOYSA-N YesY
  (verify)

Chlorisondamine is a nicotinic acetylcholine receptor antagonist that produces both neuronal and ganglionic blockade.

Chlorisondamine has been shown to form noncovalent complexes with various biomolecules including sphingomyelin and other associated glycolipids.[1][2][3]

References

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  1. ↑ Woods, A. S.; Moyer, S. C.; Wang, H. Y. J.; Wise, R. A., "Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor". Journal of Proteome Research 2003, 2 (2), 207–212.
  2. ↑ Jackson, S. N.; Wang, H. Y. J.; Woods, A. S., "Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS". Journal of the American Society for Mass Spectrometry 2005, 16 (2), 133–138.
  3. ↑ Woods, A. S.; Ugarov, M.; Egan, T.; Koomen, J.; Gillig, K. J.; Fuhrer, K.; Gonin, M.; Schultz, J. A., "Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS". Analytical Chemistry 2004, 76 (8), 2187–2195.
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