ABT-418

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ABT-418
ABT-418.png
Systematic (IUPAC) name
3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole
Identifiers
CAS Number 147402-53-7 N
PubChem CID: 119380
ChemSpider 106627 YesY
ChEMBL CHEMBL274525 YesY
Chemical data
Formula C9H14N2O
Molecular mass 166.22
  • CC1=NOC(=C1)[C@@H]2CCCN2C
  • InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1 YesY
  • Key:ILLGYRJAYAAAEW-QMMMGPOBSA-N YesY
 NYesY (what is this?)  (verify)

ABT-418 is a drug developed by Abbott, that has nootropic, neuroprotective and anxiolytic effects,[1][2][3][4] and has been researched for treatment of both Alzheimer's disease[5] and ADHD.[6][7][8] It acts as an agonist at neural nicotinic acetylcholine receptors, subtype-selective binding with high affinity to the α4β2, α7/5-HT3, and α2β2 nicotinic acetylcholine receptors but not the α3β4 subtype[9][10] familiar to nicotine. ABT-418 was reasonably effective for both applications and fairly well tolerated, but produced some side effects, principally nausea, and it is unclear whether ABT-418 itself will proceed to clinical development or if another similar drug will be used instead.[11]

See also

References

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