C16 (drug)

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C16 (drug)
C16 structure.png
Systematic (IUPAC) name
6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Identifiers
CAS Number 608512-97-6
PubChem CID: 6490494
ChemSpider 4990932
Chemical data
Formula C13H8N4OS
Molecular mass 268.293 g/mol
  • c4ncnc4\C=C3\c2c1scnc1ccc2NC3=O
  • InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
  • Key:VFBGXTUGODTSPK-BAQGIRSFSA-N

C16 or PKRi is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.[1][2][3][4][5][6]

See also

References

  1. ↑ Jammi NV, Whitby LR, Beal PA. Small molecule inhibitors of the RNA-dependent protein kinase. Biochemical and Biophysical Research Communications. 2003 Aug 15;308(1):50-7. PMID 12890478
  2. ↑ Shimazawa M, Hara H. Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress. Neuroscience Letters. 2006 Dec 6;409(3):192-5. PMID 17055645
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Couturier J, Morel M, Pontcharraud R, Gontier V, Fauconneau B, Paccalin M, Page G. Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice. Journal of Biological Chemistry. 2010 Jan 8;285(2):1272-82. PMID 19889624
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.



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