SKF-82,958

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SKF-82,958
SKF 82958.png
Systematic (IUPAC) name
3-allyl-6-chloro-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
Identifiers
CAS Number 80751-65-1
PubChem CID: 1225
ChemSpider 1188
ChEMBL CHEMBL317741
Chemical data
Formula C19H20ClNO2
Molecular mass 329.82 g/mol
  • C=CCN1CCC2=C(C(=C(C=C2C(C1)C3=CC=CC=C3)O)O)Cl

SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist.[1][2] SKF-82,958 and similar D1-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine.[3][4][5][6][7][8][9][10][11] SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen.[12][13]

References

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