Eicosanoid receptor
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An eicosanoid receptor is an integral membrane protein that detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein-coupled receptors (GPCRs). An example of a non-GPCR receptor that binds eicosanoids is PPAR-γ.[1]
The following is a list of the known human eicosanoid GPCRs grouped according to the type of eicosanoid ligand that each binds:[2][3]
Leukotriene
- BLT1 (Leukotriene B4 receptor) - LTB4R
- BLT2 (Leukotriene B4 receptor 2) - LTB4R2
- CysLT1 (Cysteinyl leukotriene receptor 1) - CYSLTR1
- CysLT2 (Cysteinyl leukotriene receptor 2) - CYSLTR2
The recently elucidated CysLTE, represented by GPR99/OXGR1, may constitute a third CysLTR.[4]
Lipoxin
- LXA4R (Formyl peptide receptor-like 1) - FPRL1
Oxoeicosanoid
Prostanoid
- PGD2: DP-(PGD2) (PGD2 receptor)
- PGE2: EP-(PGE2) (PGE2 receptor)
- PGF2α: FP-(PGF2α) (PTGFR) - PTGFR
- PGI2 (prostacyclin): IP-(PGI2) (PTGIR) - PTGIR
- TXA2 (thromboxane): TP-(TXA2) (TBXA2R) - TBXA2R
References
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- Eicosanoid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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Prostanoid signaling
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See also: Leukotrienergics
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Leukotriene signaling
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See also: Prostanoids
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