GPR119
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the GPR119 gene.[1]
GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors.[2][3][4]
Pharmacology
GPR119 is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents.[5] Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats.[5] GPR119 has also been shown to regulate incretin and insulin hormone secretion.[6][7][8] As a result, new drugs acting on the receptor have been suggested as novel treatments for obesity and diabetes.[5][7][9]
Ligands
A number of endogenous and synthetic ligands for this receptor have been identified:[10][11][12]
- 2-Oleoylglycerol [13]
- Anandamide[9]
- AR-231,453[14]
- MBX-2982[15]
- Oleoylethanolamide[2][5][9] (Endogenous Ligand) [2]
- PSN-375,963[5][6]
- PSN-632,408[5][6]
References
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