GPR35
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the GPR35 gene.[1] Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.
Ligands
Agonists
Selective agonists of GPR35 include:
- 5-nitro-2-(3-phenylpropylamino) benzoic acid[2]
- Kynurenic acid[2][3]
- Lysophosphatidic acid[2]
- Pamoic acid[2]
- Zaprinast[2][4]
Antagonists
Antagonists of GPR35 include:
Clinical significance
Deletion of GPR35 gene may be responsible for brachydactyly mental retardation syndrome and is mutated in 2q37 monosomy and 2q37 deletion syndrome.[6] In one study GPR35 has been recognised as a potential oncogene in stomach cancer.[7]
References
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