Apelin receptor

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Apelin receptor
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols APLNR ; AGTRL1; APJ; APJR; HG11
External IDs OMIM600052 MGI1346086 HomoloGene3784 IUPHAR: 36 ChEMBL: 1628481 GeneCards: APLNR Gene
Orthologs
Species Human Mouse
Entrez 187 23796
Ensembl ENSG00000134817 ENSMUSG00000044338
UniProt P35414 Q9WV08
RefSeq (mRNA) NM_005161 NM_011784
RefSeq (protein) NP_005152 NP_035914
Location (UCSC) Chr 11:
57.23 – 57.24 Mb
Chr 2:
85.14 – 85.14 Mb
PubMed search [1] [2]

The apelin receptor (also known as the APJ receptor) is a G protein-coupled receptor[1] which binds apelin [2][3][4] and Apela/ELABELA/Toddler.[5][6]

References

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  5. Chng, S. C., Ho, L., Tian, J., & Reversade, B. (2013). ELABELA: a hormone essential for heart development signals via the apelin receptor. Developmental Cell, 27(6), 672–680. doi:10.1016/j.devcel.2013.11.002
  6. Pauli, A., Norris, M.L., Valen, E., Chew, G.-L., Gagnon, J.A., Zimmerman, S., Mitchell, A., Ma, J., Dubrulle, J., Reyon, D., Tsai, S.Q., Joung, J.K., Saghatelian, A., and Schier, A.F. (2014). Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science 343, 1248636

Further reading

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External links


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