Neuropeptide Y receptor
| neuropeptide Y receptor Y1 | |
|---|---|
| Identifiers | |
| Symbol | NPY1R |
| Alt. symbols | NPYR |
| Entrez | 4886 |
| HUGO | 7956 |
| OMIM | 162641 |
| RefSeq | NM_000909 |
| UniProt | P25929 |
| Other data | |
| Locus | Chr. 4 q31.3-q32 |
| neuropeptide Y receptor Y2 | |
|---|---|
| Identifiers | |
| Symbol | NPY2R |
| Entrez | 4887 |
| HUGO | 7957 |
| OMIM | 162642 |
| RefSeq | NM_000910 |
| UniProt | P49146 |
| Other data | |
| Locus | Chr. 4 q31 |
| pancreatic polypeptide receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | PPYR1 |
| Alt. symbols | NPY4R, Y4, PP1 |
| Entrez | 5540 |
| HUGO | 9329 |
| OMIM | 601790 |
| RefSeq | NM_005972 |
| UniProt | P50391 |
| Other data | |
| Locus | Chr. 10 q11.2 |
| neuropeptide Y receptor Y5 | |
|---|---|
| Identifiers | |
| Symbol | NPY5R |
| Entrez | 4889 |
| HUGO | 7958 |
| OMIM | 602001 |
| RefSeq | NM_006174 |
| UniProt | Q15761 |
| Other data | |
| Locus | Chr. 4 q31-q32 |
Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide.[1] These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.[2][3][4][5][6][7]
Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP.
Contents
Types
There are five known mammalian neuropeptide Y receptors designated Y1 through Y5.[8] Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.[9][10][11]
Antagonists
References
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External links
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- Neuropeptide Y Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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