Pasireotide

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Pasireotide
Pasireotide.svg
Systematic (IUPAC) name
[(3S,6S,9S,12R,15S,18S,20R)-9-(4-aminobutyl)-3-benzyl-12-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-phenyl-6-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] N-(2-aminoethyl)carbamate
Clinical data
Trade names Signifor
Licence data EMA:Link
Legal status
  • ℞ (Prescription only)
Routes of
administration		 Subcutaneous
Identifiers
CAS Number 396091-73-9 YesY
ATC code H01CB05 (WHO)
PubChem CID: 9941444
IUPHAR/BPS 2018
DrugBank DB06663 N
ChemSpider 8117062
UNII 98H1T17066 YesY
KEGG D10147 N
ChEBI CHEBI:72312 N
Synonyms SOM230
Chemical data
Formula C58H66N10O9
Molecular mass 1047.21 g/mol[1]
  • C1[C@H](CN2[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C2=O)CC3=CC=CC=C3)CC4=CC=C(C=C4)OCC5=CC=CC=C5)CCCCN)CC6=CNC7=CC=CC=C76)C8=CC=CC=C8)OC(=O)NCCN
  • InChI=1S/C58H66N10O9/c59-27-13-12-22-46-52(69)64-47(30-38-23-25-42(26-24-38)76-36-39-16-6-2-7-17-39)53(70)66-49(31-37-14-4-1-5-15-37)57(74)68-35-43(77-58(75)61-29-28-60)33-50(68)55(72)67-51(40-18-8-3-9-19-40)56(73)65-48(54(71)63-46)32-41-34-62-45-21-11-10-20-44(41)45/h1-11,14-21,23-26,34,43,46-51,62H,12-13,22,27-33,35-36,59-60H2,(H,61,75)(H,63,71)(H,64,69)(H,65,73)(H,66,70)(H,67,72)/t43-,46+,47+,48-,49+,50+,51+/m1/s1
  • Key:VMZMNAABQBOLAK-DBILLSOUSA-N
 NYesY (what is this?)  (verify)

Pasireotide (SOM230, trade name Signifor[2]) is an orphan drug approved in the U.S. and Europe for the treatment of Cushing's disease and acromegaly in patients who fail or are ineligible for surgical therapy.[3][4] It was developed by Novartis. Pasireotide is a somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs.

Pasireotide was approved for Cushing's disease by the EMEA in October 2009[5] and by the FDA in December 2012.[6]

Pasireotide LAR was approved by the FDA for treatment of acromegaly in December 2014, and had been approved for this indication by the EMEA one month earlier.[7]

References

  1. ↑ Pasireotide | C58H66N10O9 - PubChem http://pubchem.ncbi.nlm.nih.gov/compound/Pasireotide
  2. ↑ Signifor® (pasireotide) Official Website for healthcare professionals outside the US http://www.signifor.com/
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ EMEA Approval for Pasireotide
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Tucker, Miriam E. FDA Approves Pasireotide for Treating Acromegaly, Medscape, December 17, 2014, Retrieved 2015-08-21



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