PipISB

PipISB

Systematic (IUPAC) name
N-(4-fluorobenzyl)-4-(3-(piperidin-1-ylindole-1-sulfonyl)benzamide
Identifiers
PubChem	CID: 58975213
Chemical data
Formula	C27H26FN3O3S
Molecular mass	491.58
SMILES O=S(N1C2=CC=CC=C2C(N3CCCCC3)=C1)(C4=CC=C(C(NCC5=CC=C(F)C=C5)=O)C=C4)=O

PipISB is a drug used in scientific research which acts as a potent and selective inverse agonist of the cannabinoid receptor CB₁. It is highly selective for the CB₁ receptor over CB₂, with a K_d at CB₁ of 1.5nM vs over 7000nM at CB₂, has good blood-brain barrier penetration, and can be conveniently radiolabelled with either ¹¹C or ¹⁸F, making it useful for mapping the distribution of CB₁ receptors in the brain.