JWH-210

JWH-210

Systematic (IUPAC) name
4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone
Clinical data
Legal status	DE: Anlage II (Prohibited) Illegal in Sweden,I-N(Poland)
Identifiers
CAS Number	824959-81-1 Y (JWH-210) Template:CAS (JWH-182)
PubChem	CID: 45270396
ChemSpider	24617616
Chemical data
Formula	C26H27NO
Molecular mass	369.498 g/mol
SMILES c4cccc2c4c(CC)ccc2C(=O)c(c3)c1ccccc1n3CCCCC
InChI InChI=1S/C26H27NO/c1-3-5-10-17-27-18-24(22-13-8-9-14-25(22)27)26(28)23-16-15-19(4-2)20-11-6-7-12-21(20)23/h6-9,11-16,18H,3-5,10,17H2,1-2H3 Key:LACIUQLUNACUKC-UHFFFAOYSA-N
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JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB₁ and CB₂ receptors, with K_i values of 0.46nM at CB₁ and 0.69nM at CB₂. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower K_i) at CB₁ than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB₁ K_i 0.69nM) and JWH-182 (CB₁ K_i 0.65nM) respectively, and than the 4-methoxy compound JWH-081 (CB₁ K_i 1.2nM). It was discovered by and named after Dr. John W. Huffman.

JWH-210 may be neurotoxic to animals when administered in high doses.

Legal Status

JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" synthetic cannabis products. The substances JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.

As of October 2015 JWH-210 is a controlled substance in China.

See also

• JWH-081
• JWH-193
• JWH-398