Niflumic acid

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Niflumic acid
Niflumic acid.png
Systematic (IUPAC) name
2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
Clinical data
AHFS/Drugs.com International Drug Names
Pharmacokinetic data
Biological half-life 2.5 hr[1]
Identifiers
CAS Number 4394-00-7 YesY
ATC code M01AX02 (WHO) M02AA17
PubChem CID: 4488
IUPHAR/BPS 2439
ChemSpider 4333 N
UNII 4U5MP5IUD8 N
KEGG D08275 YesY
ChEMBL CHEMBL63323 N
Chemical data
Formula C13H9F3N2O2
Molecular mass 282.21797 g/mol
  • C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
  • InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) N
  • Key:JZFPYUNJRRFVQU-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels.[2] It has also been reported to act on GABA-A[3] and NMDA channels[4] and to block T-type calcium channels.[5]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Sinkkonen ST et al. (2003): Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug, Mol Pharmacol, p. 753-63. PMID 12920213
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Balderas E et al. (2012): Niflumic acid blocks native and recombinant T-type channels, J Cell Physiol, p. 2542-55. PMID 21898399



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