Tetrahydrodeoxycorticosterone

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Tetrahydrodeoxycorticosterone
Tetrahydrodeoxycorticosterone.png
Systematic (IUPAC) name
(3α,5β)-3,21-dihydroxypregnan-20-one
Identifiers
CAS Number 567-03-3 YesY
PubChem CID: 91475
Synonyms THDOC
Chemical data
Formula C21H34O3
Molecular mass 334.493 g/mol
  • C[C@]12CCC(C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O
  (verify)

Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid.[1] It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase.[2] THDOC is a potent positive allosteric modulator of the GABAA receptor, and has sedative, anxiolytic and anticonvulsant effects.[3][4][5] Changes in the normal levels of this steroid particularly during pregnancy and menstruation may be involved in some types of epilepsy (catamenial epilepsy) and premenstrual syndrome,[6] as well as stress, anxiety and depression.[7][8][9][10][11]

See also

References

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