Butyrophenone

Butyrophenone

Names
IUPAC name 1-phenylbutan-1-one
Identifiers
CAS Number	495-40-9 Y
ChEMBL	ChEMBL193524 Y
ChemSpider	9893 Y
Jmol 3D model	Interactive image Interactive image
PubChem	10315
InChI InChI=1S/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3 Y Key: FFSAXUULYPJSKH-UHFFFAOYSA-N Y InChI=1/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3 Key: FFSAXUULYPJSKH-UHFFFAOYAC
SMILES O=C(c1ccccc1)CCC CCCC(=O)c1ccccc1
Properties
Chemical formula	C10H12O
Molar mass	148.20 g/mol
Appearance	colorles liquid
Melting point	12 °C (54 °F; 285 K)
Boiling point	229 °C (444 °F; 502 K)
Solubility in water	negligible
log P	2.77
Refractive index (nD)	1.520
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Butyrophenone is a chemical compound; some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.

Butyrophenones are a class of pharmaceutical drugs derived from butyrophenone.

Examples include:

• Haloperidol, the most widely used classical antipsychotic drug in this class
• Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
• Benperidol, the most potent commonly used antipsychotic ( 200 times more potent than chlorpromazine)
• Trifluperidol, a highly potent antipsychotic (100 times more potent than chlorpromazine)
• Melperone, a weakly potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, in particular, in geriatric patients
• Lenperone
• Azaperone, used in veterinary medicine
• Domperidone, a dopamine-antagonist antiemetic, derived further from butyrophenone (not being a butyrophenone itself).
• Fluanisone
• Penfluridol
• Pipamperone
• Spiperone (more potent neuroleptic than benperidol)
• Nonaperone

The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and ketanserin as a basis.

Ketocaine is a butyrophenone local anesthetic.