Thenalidine

Thenalidine
Systematic (IUPAC) name
	1-Methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine
Identifiers
CAS Number	86-12-4
ATC code	D04AA03 (WHO) R06AX03; R06AX53 (combinations)
PubChem	CID: 27901
DrugBank	DB04826
ChemSpider	25957
UNII	6U94N2D00F
KEGG	D07194
Chemical data
Formula	C17H22N2S
Molecular mass	286.436 g/mol
	SMILES s1c(ccc1)CN(c2ccccc2)C3CCN(C)CC3 ;
	InChI InChI=1S/C17H22N2S/c1-18-11-9-16(10-12-18)19(14-17-8-5-13-20-17)15-6-3-2-4-7-15/h2-8,13,16H,9-12,14H2,1H3 ; Key:KLOHYVOVXOUKQI-UHFFFAOYSA-N ;
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Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug.^[1] It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of neutropenia.^[2]

References

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v t e Antipruritics (D04)
Antihistamines for topical use	Thonzylamine Mepyramine Thenalidine Tripelennamine Chloropyramine Promethazine Tolpropamine Dimetindene Clemastine Bamipine Isothipendyl Diphenhydramine Chlorphenoxamine
Anesthetics for topical use	Lidocaine Dibucaine Oxybuprocaine Benzocaine Quinisocaine Tetracaine Pramocaine
Others	Corticosteroids (e.g., hydrocortisone) Counterirritants (e.g., mint oil, menthol, camphor) Nalfurafine