Thonzylamine

Thonzylamine
Systematic (IUPAC) name
	N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	91-85-0 Template:CAS
ATC code	D04AA01 (WHO) R01AC06 R06AC06
PubChem	CID: 5457
ChemSpider	5258
UNII	R79646H5Z8
KEGG	D08587
ChEMBL	CHEMBL1623738
Synonyms	Neohetramine
Chemical data
Formula	C16H22N4O
Molecular mass	286.372 g/mol
	SMILES n1cccnc1N(CCN(C)C)Cc2ccc(OC)cc2 ;
	InChI InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3 ; Key:GULNIHOSWFYMRN-UHFFFAOYSA-N ;
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Thonzylamine (or neohetramine)^[1] is an antihistamine and anticholinergic used as an antipruritic.

Synthesis

Thonzylamine synthesis: H. L. Friedman and A, V. Tolstouhov, U.S. Patent 2,465,865 (1949).

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v t e Antipruritics (D04)
Antihistamines for topical use	Thonzylamine Mepyramine Thenalidine Tripelennamine Chloropyramine Promethazine Tolpropamine Dimetindene Clemastine Bamipine Isothipendyl Diphenhydramine Chlorphenoxamine
Anesthetics for topical use	Lidocaine Dibucaine Oxybuprocaine Benzocaine Quinisocaine Tetracaine Pramocaine
Others	Corticosteroids (e.g., hydrocortisone) Counterirritants (e.g., mint oil, menthol, camphor) Nalfurafine

Systematic (IUPAC) name

N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	91-85-0^N Template:CAS
ATC code	D04AA01 (WHO) R01AC06 R06AC06
PubChem	CID: 5457
ChemSpider	5258^Y
UNII	R79646H5Z8^Y
KEGG	D08587^Y
ChEMBL	CHEMBL1623738^N
Synonyms	Neohetramine
Chemical data
Formula	C₁₆H₂₂N₄O
Molecular mass	286.372 g/mol
SMILES n1cccnc1N(CCN(C)C)Cc2ccc(OC)cc2
InChI InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3^Y Key:GULNIHOSWFYMRN-UHFFFAOYSA-N^Y

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