Hypidone

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Systematic (IUPAC) name
	1-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]pyridin-2-one
Identifiers
CAS Number	1339339-18-2; 1339058-04-6 (HCl)
PubChem	CID: 54673543
ChemSpider	68055492
Synonyms	YL-0919; YL0919
Chemical data
Formula	C18H22N2O2
Molecular mass	298.39 g·mol−1
	SMILES C1CN(CCC1(CN2C=CC=CC2=O)O)CC3=CC=CC=C3 ;
	InChI InChI=1S/C18H22N2O2/c21-17-8-4-5-11-20(17)15-18(22)9-12-19(13-10-18)14-16-6-2-1-3-7-16/h1-8,11,22H,9-10,12-15H2 ; Key:BGMVOROUOUVVRV-UHFFFAOYSA-N ;

Hypidone (developmental code name YL-0919) is an investigational serotonergic antidepressant which is under development for the treatment of major depressive disorder.^[1]^[2]^[3]^[4]^[5] It acts as a serotonin reuptake inhibitor, 5-HT_1A receptor partial agonist, and 5-HT₆ receptor full agonist.^[1]^[5] It is used as the hydrochloride salt.^[2]^[5] As of January 2021, hypidone is in phase 2 clinical trials for major depressive disorder.^[1]

References

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