Batanopride

Batanopride
Systematic (IUPAC) name
	4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(3-oxobutan-2-yloxy)benzamide
Clinical data
Legal status	Uncontrolled;
Routes of; administration	Oral
Identifiers
CAS Number	102670-46-2
ATC code	none
PubChem	CID: 59692
ChemSpider	53849
UNII	1AT99K728N
ChEMBL	CHEMBL38594
Chemical data
Formula	C17H26ClN3O3
Molecular mass	355.860 g/mol
	SMILES Clc1cc(c(OC(C(=O)C)C)cc1N)C(=O)NCCN(CC)CC ;
	InChI InChI=1S/C17H26ClN3O3/c1-5-21(6-2)8-7-20-17(23)13-9-14(18)15(19)10-16(13)24-12(4)11(3)22/h9-10,12H,5-8,19H2,1-4H3,(H,20,23) ; Key:ZYOJXUNLLOBURP-UHFFFAOYSA-N ;
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Batanopride (BMY-25,801) is an antiemetic drug of the benzamide class which acts as a selective 5-HT₃ receptor antagonist.^[1] It was trialled to reduce nausea during cancer chemotherapy, but was never approved for medical use due to dose-limiting side effects including hypotension and long QT syndrome.^[2]

References

↑ Gylys JA, Wright RN, Nicolosi WD, Buyniski JP, Crenshaw RR. BMY-25801, an antiemetic agent free of D2-dopamine receptor antagonist properties. Journal of Pharmacology and Experimental Therapeutics. 1988 Mar;244(3):830-7. PMID 2978041
↑ Fleming GF, Vokes EE, McEvilly JM, Janisch L, Francher D, Smaldone L. Double-blind, randomized crossover study of metoclopramide and batanopride for prevention of cisplatin-induced emesis. Cancer Chemotherapy and Pharmacology. 1991;28(3):226-7. PMID 1855280

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