TEK tyrosine kinase
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene.[1][2]
Function
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.[3]
Interactions
TEK tyrosine kinase has been shown to interact with:
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References
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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