CD58
| CD58 molecule | |
|---|---|
| Identifiers | |
| Symbol | CD58 |
| Alt. symbols | LFA3 |
| Entrez | 965 |
| HUGO | 1688 |
| OMIM | 153420 |
| RefSeq | NM_001779 |
| UniProt | P19256 |
| Other data | |
| Locus | Chr. 1 p13 |
CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages.[1][2]
It binds to CD2 (LFA-2) [3][4] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to.
Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.[5]
References
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External links
- CD58 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
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