CD120
From Infogalactic: the planetary knowledge core
| tumor necrosis factor receptor superfamily, member 1A | |
|---|---|
| Identifiers | |
| Symbol | TNFRSF1A |
| Alt. symbols | CD120a, TNFR1 |
| Entrez | 7132 |
| HUGO | 11916 |
| OMIM | 191190 |
| RefSeq | NM_001065 |
| UniProt | P19438 |
| Other data | |
| Locus | Chr. 12 p13.2 |
| tumor necrosis factor receptor superfamily, member 1B | |
|---|---|
| Identifiers | |
| Symbol | TNFRSF1B |
| Alt. symbols | CD120a, TNFR2 |
| Entrez | 7133 |
| HUGO | 11917 |
| OMIM | 191191 |
| RefSeq | NM_001066 |
| UniProt | P20333 |
| Other data | |
| Locus | Chr. 1 p36.22 |
CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).[1][2]
Receptor subtypes
There are two variants of the receptor, each encoded by a separate gene:
- CD120a - TNFR1 - TNFR superfamily member 1A
- CD120b - TNFR2 - TNFR superfamily member 1B
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]
Signaling pathway
Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps
See also
References
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<references />, or <references group="..." />External links
- CD120a Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- CD120b Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
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