Related to receptor tyrosine kinase

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk. The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.

History

The gene encoding mouse RYK was first identified in 1992. Subsequently cDNA encoding the RYK protein have been isolated from the following species.

• rat
• chicken
• Human
• Zebrafish
• Drosophila and
• C. elegans

Structure

In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal domain, an extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.

Function

RYK is involved in regulation of axon growth during development of the nervous system.