SIX2

SIX homeobox 2
Identifiers
Symbol	SIX2
External IDs	OMIM: 604994 MGI: 102778 HomoloGene: 56518 GeneCards: SIX2 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding • protein complex binding Cellular component • nucleus • nucleoplasm • cytoplasm • plasma membrane • nuclear membrane Biological process • kidney development • chondrocyte differentiation • mesenchymal to epithelial transition involved in metanephros morphogenesis • transcription from RNA polymerase II promoter • protein import into nucleus • mesodermal cell fate specification • cell proliferation • anatomical structure morphogenesis • anterior/posterior axis specification • cell migration • regulation of ossification • regulation of chondrocyte differentiation • middle ear morphogenesis • positive regulation of transcription from RNA polymerase II promoter • embryonic digestive tract morphogenesis • embryonic cranial skeleton morphogenesis • nephron development • nephron morphogenesis • mesenchymal stem cell maintenance involved in nephron morphogenesis • mesenchymal cell differentiation involved in kidney development • regulation of branching involved in ureteric bud morphogenesis • mesenchymal stem cell proliferation • positive regulation of chondrocyte proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10736	20472
Ensembl	ENSG00000170577	ENSMUSG00000024134
UniProt	Q9NPC8	Q62232
RefSeq (mRNA)	NM_016932	NM_011380
RefSeq (protein)	NP_058628	NP_035510
Location (UCSC)	Chr 2: 45.01 – 45.01 Mb	Chr 17: 85.68 – 85.69 Mb
PubMed search	[1]	[2]

Homeobox protein SIX2 is a protein that in humans is encoded by the SIX2 gene.