KLF14
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene.[1] The corresponding Klf14 mouse gene is known as Sp6.[2]
Function
KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ).[3] KLF14 is expressed in many tissues,[4] lacks introns, and is subject to parent-specific expression.[5]
KLF14 appears to be a master regulator of gene expression in adipose tissue.[6]
Protein structure
Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.[7]
Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124;[7] in the mouse its length is 325.[8]
Clinical significance
There appears to be a connection between KLF14 and coronary artery disease, hypercholesterolemia and type 2 diabetes.[9][10]
References
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- ↑ Online 'Mendelian Inheritance in Man' (OMIM) Krüppel-like factor 14 -609393
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External links
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