MNT (gene)
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Max-binding protein MNT is a protein that in humans is encoded by the MNT gene.[1][2]
Function
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.[2]
Interactions
MNT (gene) has been shown to interact with MLX,[3][4] SIN3A[5] and MAX.[5]
References
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External links
- MNT protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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