PRRX2

Paired related homeobox 2
Identifiers
Symbols	PRRX2 ; PMX2; PRX2
External IDs	OMIM: 604675 MGI: 98218 HomoloGene: 7524 GeneCards: PRRX2 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding Cellular component • nucleus Biological process • positive regulation of mesenchymal cell proliferation • regulation of transcription, DNA-templated • embryonic limb morphogenesis • inner ear morphogenesis • middle ear morphogenesis • positive regulation of smoothened signaling pathway • embryonic cranial skeleton morphogenesis • artery morphogenesis • cartilage development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51450	20204
Ensembl	ENSG00000167157	ENSMUSG00000039476
UniProt	Q99811	Q06348
RefSeq (mRNA)	NM_016307	NM_009116
RefSeq (protein)	NP_057391	NP_033142
Location (UCSC)	Chr 9: 129.67 – 129.72 Mb	Chr 2: 30.83 – 30.88 Mb
PubMed search	[1]	[2]

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.

Function

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.