Glycoprotein Ib
From Infogalactic: the planetary knowledge core
(Redirected from CD42)
Glycoprotein Ib (GPIb), also known as CD42,[1] is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular injury.
It is deficient in the Bernard-Soulier syndrome. A gain-of-function mutation causes platelet-type von Willebrand's disease.[2]
Autoantibodies against Ib/IX can be produced in immune thrombocytopenic purpura.[3]
Components include GP1BA and GP1BB.
It complexes with Glycoprotein IX.
References
External links
- Glycoprotein Ib at the US National Library of Medicine Medical Subject Headings (MeSH)
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