Alpha 2-antiplasmin

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
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Identifiers
Symbols	SERPINF2 ; A2AP; AAP; ALPHA-2-PI; API; PLI
External IDs	OMIM: 613168 MGI: 107173 HomoloGene: 719 GeneCards: SERPINF2 Gene
Gene ontology Molecular function • protease binding • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity • protein binding • protein homodimerization activity Cellular component • extracellular region • fibrinogen complex • extracellular space • cell surface • platelet alpha granule lumen • extracellular exosome • blood microparticle Biological process • regulation of blood vessel size by renin-angiotensin • platelet degranulation • acute-phase response • blood coagulation • response to organic substance • negative regulation of plasminogen activation • negative regulation of endopeptidase activity • platelet activation • collagen fibril organization • positive regulation of collagen biosynthetic process • fibrinolysis • positive regulation of cell differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • blood vessel morphogenesis • positive regulation of smooth muscle cell proliferation • positive regulation of stress fiber assembly • negative regulation of fibrinolysis • positive regulation of ERK1 and ERK2 cascade • positive regulation of transforming growth factor beta production • positive regulation of cell-cell adhesion mediated by cadherin Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SERPINF2 205075 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5345	18816
Ensembl	ENSG00000167711	ENSMUSG00000038224
UniProt	P08697	Q61247
RefSeq (mRNA)	NM_000934	NM_008878
RefSeq (protein)	NP_000925	NP_032904
Location (UCSC)	Chr 17: 1.74 – 1.76 Mb	Chr 11: 75.43 – 75.44 Mb
PubMed search	[1]	[2]

Alpha 2-antiplasmin (or α₂-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.

Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.

Role in disease

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. This is associated with an increase risk of bleeding in liver disease.

Interactions

Alpha 2-antiplasmin has been shown to interact with:

• Neutrophil elastase and
• Plasmin.

See also

• Serpin

External links

• The MEROPS online database for peptidases and their inhibitors: I04.023
• alpha-2 Antiplasmin at the US National Library of Medicine Medical Subject Headings (MeSH)
• SERPINF2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)