Oliceridine

Systematic (IUPAC) name
	N-[(3-methoxythiophen-2-yl)methyl]-2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethanamine
Clinical data
Legal status	Investigational New Drug;
Routes of; administration	IV
Identifiers
CAS Number	1401028-24-7
ATC code	none
PubChem	CID: 66553195
ChemSpider	30841043
UNII	MCN858TCP0
ChEMBL	CHEMBL2443262
Synonyms	TRV130
Chemical data
Formula	C22H30N2O2S
Molecular mass	386.55 g·mol−1
	SMILES COc1ccsc1CNCC[C@]2(CCOC3(CCCC3)C2)c4ccccn4 ;
	InChI InChI=1S/C22H30N2O2S/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3/t21-/m1/s1 ; Key:DMNOVGJWPASQDL-OAQYLSRUSA-N ;

Oliceridine (TRV130) is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. It is a functionally selective μ-opioid receptor agonist developed by Trevena Inc. Oliceridine elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less β-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine.^[1]^[2]^[3]^[4]

References

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