6'-Guanidinonaltrindole
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| Properties | |
|---|---|
| C27H29N5O3 | |
| Molar mass | 471.56 g·mol−1 |
| Vapor pressure | {{{value}}} |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
6'-Guanidinonaltrindole (6'-GNTI) is a κ−δ-opioid receptor selective ligand used in scientific research.[1]
With 6'-GNTI, evidence was provided for the first time that receptor oligomizeration plays functional role in living organisms.[2]
6'-GNTI is an extremely biased agonist of the κ-opioid receptor.[3] It is a potent partial agonist of the G protein pathway but does not recruit the β-arrestin pathway.[3] Due to its functional selectivity for the G protein pathway, 6'-GNTI functions as an antagonist of nonbiased KOR agonists on the β-arrestin pathway.[3] It is thought that 6'-GTNI may be able to produce analgesia without dysphoria and with a lower incidence of tolerance.[3]
See also
References
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- ↑ Rives ML, Rossillo M, Liu-Chen LY, Javitch JA (2012): J Biol Chem, 287(32):27050-4. PMID 22736766
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