KLRD1

Killer cell lectin-like receptor subfamily D, member 1
PDB rendering based on 1b6e.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1B6E, 3BDW, 3CDG, 3CII
Identifiers
Symbols	KLRD1 ; CD94
External IDs	OMIM: 602894 MGI: 1196275 HomoloGene: 1705 GeneCards: KLRD1 Gene
Gene ontology Molecular function • transmembrane signaling receptor activity • protein binding • MHC class I protein complex binding • MHC class Ib protein binding, via antigen binding groove • carbohydrate binding • protein antigen binding Cellular component • plasma membrane • external side of plasma membrane • integral component of membrane • receptor complex Biological process • natural killer cell mediated immunity • cell surface receptor signaling pathway • innate immune response • regulation of immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3824	16643
Ensembl	ENSG00000134539	ENSMUSG00000030165
UniProt	Q13241	O54707
RefSeq (mRNA)	NM_001114396	NM_010654
RefSeq (protein)	NP_001107868	NP_034784
Location (UCSC)	Chr 12: 10.23 – 10.33 Mb	Chr 6: 129.59 – 129.6 Mb
PubMed search	[1]	[2]

CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene.

The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Function

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.

Interactions

KLRD1 has been shown to interact with KLRC2.

See also

• Cluster of differentiation

External links

• CD94 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)