CCL24
| chemokine (C-C motif) ligand 24 | |
|---|---|
| Identifiers | |
| Symbol | CCL24 |
| Alt. symbols | SCYA24, Ckb-6, MPIF-2, eotaxin-2 |
| Entrez | 6369 |
| HUGO | 10623 |
| OMIM | 602495 |
| PDB | 1EIG |
| RefSeq | NM_002991 |
| UniProt | O00175 |
| Other data | |
| Locus | Chr. 7 q11.23 |
Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2) is a protein that in humans is encoded by the CCL24 gene.[1] This gene is located on human chromosome 7.[2]
Function
CCL24 is a small cytokine belonging to the CC chemokine family. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils.[3] This chemokine is also strongly chemotactic for resting T lymphocytes and slightly chemotactic for neutrophils.[1]
Clinical significance
Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.[4]
References
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