Interleukin 25

Interleukin 25
Identifiers
Symbols	IL25 ; IL17E
External IDs	OMIM: 605658 MGI: 2155888 HomoloGene: 15429 GeneCards: IL25 Gene
Gene ontology Molecular function • cytokine activity • interleukin-17E receptor binding Cellular component • extracellular space Biological process • inflammatory response to antigenic stimulus • biological_process • response to fungus • response to nematode • eosinophil differentiation • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE IL25 220971 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64806	140806
Ensembl	ENSG00000166090	ENSMUSG00000040770
UniProt	Q9H293	Q8VHH8
RefSeq (mRNA)	NM_022789	NM_080729
RefSeq (protein)	NP_073626	NP_542767
Location (UCSC)	Chr 14: 23.37 – 23.38 Mb	Chr 14: 54.93 – 54.94 Mb
PubMed search	[1]	[2]

Interleukin-25 (IL-25) – also known as interleukin-17E (IL-17E) – is a protein that in humans is encoded by the IL25 gene.

Function

IL-25 is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-κB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17RB. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

IL-25 is a cytokine that belongs to the IL-17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells.

Clinical significance

IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, which stimulate the expansion of eosinophils. This cytokine is an important molecule controlling immunity of the gut and has been implicated in chronic inflammation associated with the gastrointestinal tract. IL-25 can kill some types of breast cancer cells.

Further, the IL-25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD), although no direct evidence suggests that IL-25 plays any role in this disease.