Villoglandular adenocarcinoma of the cervix
| Villoglandular adenocarcinoma of the cervix | |
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Micrograph of a villoglandular adenocarcinoma the cervix. H&E stain.
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| Classification and external resources | |
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| Patient UK | Villoglandular adenocarcinoma of the cervix |
Villoglandular adenocarcinoma of the cervix, also villoglandular papillary adenocarcinoma, papillary villoglandular adenocarcinoma and well-differentiated villoglandular adenocarcinoma, abbreviated VGA, is a rare type of cervical cancer that, in relation to other cervical cancers, is typically found in younger women and has a better prognosis.[1]
A similar lesion, villoglandular adenocarcinoma of the endometrium, may arise from the inner lining of the uterus, the endometrium.[2]
Signs and symptoms
The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.
Diagnosis
The diagnosis is based on tissue examination, e.g. biopsy.
The name of the lesion describes it microscopic appearance. It has nipple-like structures with fibrovascular cores (papillae) that are long in relation to their width (villus-like), which are covered with a glandular pseudostratified columnar epithelium.
Treatment
The treatment is dependent on the stage. As the prognosis of this tumour is usually good, fertility sparing approaches (conization, cervicectomy) may be viable treatment options.
See also
Additional images
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Villoglandular adenocarcinoma - very low mag.jpg
Very low mag.
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Villoglandular adenocarcinoma - intermed mag.jpg
Intermed. mag.
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Villoglandular adenocarcinoma - very high mag.jpg
Very high mag.
