Sertoli cell tumour
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| Sertoli cell tumour | |
|---|---|
Micrograph of a Sertoli cell tumour. H&E stain.
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| Classification and external resources | |
| Specialty | Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value). |
| ICD-9-CM | 183.0, 256.1 |
| ICD-O | 8631 |
| Patient UK | Sertoli cell tumour |
| MeSH | D012707 |
A Sertoli cell tumour, also Sertoli cell tumor (US spelling), is a Sex cord-gonadal stromal tumor of a Sertoli cells. Although Sertoli cells normally occur only in the testis, this type of tumor may also rarely occur in the ovary of females.[1]
A tumor that produces both Sertoli cells and Leydig cells is known as a Sertoli-Leydig cell tumor.
Contents
Presentation
Due to excess estrogen secreted by these tumours, one-third of male patients may present with a recent history of progressive feminization.
Diagnosis
Presence of an ovarian tumour plus hormonal disturbances suggests a Leydig cell tumour, granulosa cell tumour or thecoma. However, hormonal disturbances, in Leydig tumours, is present in only 2/3 of cases. A conclusive diagnosis is made via histology, as part of a pathology report made during or after surgery. See also Sex cord-stromal tumour.
Treatment
The usual treatment is surgery. The surgery in women is usually a fertility-sparing unilateral salpingo-oophorectomy. For malignant tumours, the surgery may be radical and usually is followed by adjuvant chemotherapy, sometimes by radiation therapy. In all cases, initial treatment is followed by surveillance. Because in many cases Leydig cell tumour does not produce elevated tumour markers,[2] the focus of surveillance is on repeated physical examination and imaging.
The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant.[citation needed] For malignant tumours with undifferentiated histology, prognosis is poor.[2]
In non-humans
Sertoli cell tumors are known to occur in other species, including domestic ducks,[3] dogs,[4][5] and horses.
Additional images
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Micrograph of a Leydig cell tumour.
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Micrograph of a Leydig cell tumour.
See also
Notes
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