Brenner tumour
| Brenner tumor | |
|---|---|
| File:Brenner Tumor of Ovary.jpg
A Brenner tumour of ovary (gross image).
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| Classification and external resources | |
| Specialty | Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value). |
| ICD-9-CM | 220 |
| ICD-O | 9000 |
| DiseasesDB | 33431 |
| Patient UK | Brenner tumour |
| MeSH | D001948 |
Brenner tumors are an uncommon subtype of the surface epithelial-stromal tumor group of ovarian neoplasms. The majority are benign, but some can be malignant.[1]
They are most frequently found incidentally on pelvic examination or at laparotomy.[2] Brenner tumours very rarely can occur in other locations, including the testes.[3]
Contents
Presentation
On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumours can vary in size from less than 1 centimetre (0.39 in) to 30 centimetres (12 in). Borderline and malignant Brenner tumours are possible but each are rare.
Diagnosis
Histologically, there are nests of transitional epithelial (urothelial) cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma.
Similar conditions
Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour.
Eponym
It is named for Fritz Brenner, who characterized it in 1907.[4] The term "Brenner tumor" was first used by Robert Meyer, in 1932.[5]
Additional images
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Walthard cell rest - very high mag.jpg
Micrograph of a Walthard cell nest, the entity Brenner tumours are thought to arise from. H&E stain.
References
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External links
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- Histology at University of Utah
