Talarozole

Talarozole

File:Talarozole skeletal.svg
Systematic (IUPAC) name
N-(2-Benzothioazolyl)-N-[4-[2-ethyl-1-(1,2,4-triazo-1-yl)butyl]phenyl]amine
Clinical data
Routes of administration	oral, topical
Identifiers
CAS Number	201410-53-9 Y
ATC code	none
PubChem	CID: 9799888
ChemSpider	7975653 N
UNII	XKD9N5CJ6W Y
ChEBI	CHEBI:101854 Y
Chemical data
Formula	C21H23N5S
Molecular mass	377.505 g/mol
SMILES c2ncnn2C(C(CC)CC)c(cc3)ccc3Nc4nc1ccccc1s4
InChI InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25) N Key:SNFYYXUGUBUECJ-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Talarozole (formerly R115866, planned trade name Rambazole) is an investigational drug for the treatment of acne, psoriasis and other keratinization disorders.

Talarozole inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase. Because of this mechanism, it is called a retinoic acid metabolism blocking agent (RAMBA).