SLC19A1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Solute carrier family 19 (folate transporter), member 1, also known as SLC19A1 or RFC1, is a protein which in humans is encoded by the SLC19A1 gene.[1]
Function
Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[2]
Clinical significance
Individuals carrying a specific polymorphism of SLC19A1 (c.80GG) have lower levels of folate.[3] Other studies have also shown that individuals carrying the c.80AA polymrophism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent. Personalized dosing of the drug depending on the patient's genotype may therefore be required.
See also
References
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
