Nomegestrol acetate

Nomegestrol acetate

Systematic (IUPAC) name
(17α)-17-acetyl-6-methyl-3-oxoestra-4,6-dien-17-yl acetate
Clinical data
Legal status	℞ (Prescription only)
Routes of administration	Oral
Identifiers
CAS Number	58652-20-3
ATC code	G03DB04 (WHO)
PubChem	CID: 91668
ChemSpider	82771
Chemical data
Formula	C23H30O4
Molecular mass	370.482 g/mol
SMILES O=C4\C=C3\C(=C/[C@@H]1[C@H](CC[C@@]2([C@@](OC(=O)C)(C(=O)C)CC[C@@H]12)C)[C@H]3CC4)C
InChI InChI=1S/C23H30O4/c1-13-11-20-18(17-6-5-16(26)12-19(13)17)7-9-22(4)21(20)8-10-23(22,14(2)24)27-15(3)25/h11-12,17-18,20-21H,5-10H2,1-4H3/t17-,18-,20-,21+,22+,23+/m1/s1 Key:IIVBFTNIGYRNQY-YQLZSBIMSA-N

Nomegestrol acetate (INN; Lutenyl), or 19-normegestrol acetate, is a steroidal progestin with additional antigonadotropic effects which was introduced in 1986 and is used as a hormonal contraceptive. Unlike many other steroidal progestogens, it is selective for the progesterone receptor, lacking any significant affinity for other steroid receptors such as the androgen, estrogen, glucocorticoid, and mineralocorticoid receptors. As a result, it does not possess any androgenic, estrogenic, glucocorticoid, or mineralocorticoid effects. However, at sufficiently high doses it does have potent antiestrogenic and antiandrogenic effects due to its progesterone receptor-mediated antigonadotropic properties.

The combination with estradiol is also used as a hormonal contraceptive and approved in Europe under the name Zoely.

See also

• Nomegestrol
• Demegestone
• Trimegestone
• Megestrol acetate
• Progestin