FLT4

Fms-related tyrosine kinase 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4BSJ, 4BSK
Identifiers
Symbols	FLT4 ; FLT41; LMPH1A; PCL; VEGFR3
External IDs	OMIM: 136352 MGI: 95561 HomoloGene: 7321 ChEMBL: 1955 GeneCards: FLT4 Gene
EC number	2.7.10.1
Gene ontology Molecular function • transmembrane receptor protein tyrosine kinase activity • vascular endothelial growth factor-activated receptor activity • protein binding • ATP binding • growth factor binding • protein phosphatase binding Cellular component • extracellular region • nucleus • cytoplasm • plasma membrane • integral component of plasma membrane • receptor complex Biological process • positive regulation of protein phosphorylation • positive regulation of endothelial cell proliferation • vasculature development • lymph vessel development • lymphangiogenesis • sprouting angiogenesis • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell proliferation • positive regulation of vascular endothelial growth factor production • positive regulation of endothelial cell migration • peptidyl-tyrosine phosphorylation • cellular response to vascular endothelial growth factor stimulus • vascular endothelial growth factor signaling pathway • negative regulation of apoptotic process • positive regulation of MAPK cascade • positive regulation of JNK cascade • protein autophosphorylation • vascular endothelial growth factor receptor signaling pathway • blood vessel morphogenesis • regulation of blood vessel remodeling • positive regulation of ERK1 and ERK2 cascade • positive regulation of protein kinase C signaling Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2324	14257
Ensembl	ENSG00000037280	ENSMUSG00000020357
UniProt	P35916	P35917
RefSeq (mRNA)	NM_002020	NM_008029
RefSeq (protein)	NP_002011	NP_032055
Location (UCSC)	Chr 5: 180.6 – 180.65 Mb	Chr 11: 49.61 – 49.65 Mb
PubMed search	[1]	[2]

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.

Interactions

FLT4 has been shown to interact with SHC1.

See also

• VEGF receptors

External links

• GeneReviews/NCBI/NIH/UW entry on Milroy Disease

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.