Cefpirome

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Cefpirome
File:Cefpirome.svg
Systematic (IUPAC) name
1-{[(6R,7R)-7-[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-5H,6H,7H-cyclopenta[b]pyridin-1-ium
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
CAS Number 84957-29-9 YesY
ATC code J01DE02 (WHO)
PubChem CID: 6917674
ChemSpider 23089536 N
UNII S72Q2F09HY YesY
KEGG D07649 YesY
ChEMBL CHEMBL2106076 N
Chemical data
Formula C22H22N6O5S2
Molecular mass 514.58 g/mol
  • CON=C(c1csc(n1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[n+]4cccc5c4CCC5)C(=O)[O-]
  • InChI=1S/C22H22N6O5S2/c1-33-26-15(13-10-35-22(23)24-13)18(29)25-16-19(30)28-17(21(31)32)12(9-34-20(16)28)8-27-7-3-5-11-4-2-6-14(11)27/h3,5,7,10,16,20H,2,4,6,8-9H2,1H3,(H3-,23,24,25,29,31,32)/b26-15-/t16-,20+/m1/s1 N
  • Key:DKOQGJHPHLTOJR-XECLGWKCSA-N N
 NYesY (what is this?)  (verify)

Cefpirome is a fourth-generation cephalosporin. Trade names include Cefrom, Keiten, Broact, and Cefir. Cefpirome is considered highly active against Gram-negative bacteria, including Pseudomonas aeruginosa, and Gram-positive bacteria.

Spectrum of bacterial susceptibility and resistance

Bacteroides fragilis, enterococci, Pseudomonas spp. and staphylococci are resistant to cefpirome sulfate, and some Haemophilus spp. and pneumococci have developed resistance to it to varying degrees.[1]

References

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