TRPC5

Transient receptor potential cation channel, subfamily C, member 5
Identifiers
Symbols	TRPC5 ; PPP1R159; TRP5
External IDs	OMIM: 300334 MGI: 109524 HomoloGene: 74915 IUPHAR: 490 ChEMBL: 1250411 GeneCards: TRPC5 Gene
Gene ontology Molecular function • calcium channel activity • protein binding • store-operated calcium channel activity • inositol 1,4,5 trisphosphate binding Cellular component • cytosol • plasma membrane • integral component of plasma membrane • calcium channel complex Biological process • calcium ion transport • manganese ion transport • nervous system development • axon guidance • ion transmembrane transport • cytosolic calcium ion homeostasis • transmembrane transport • calcium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE TRPC5 220552 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7224	22067
Ensembl	ENSG00000072315	ENSMUSG00000041710
UniProt	Q9UL62	Q9QX29
RefSeq (mRNA)	NM_012471	NM_009428
RefSeq (protein)	NP_036603	NP_033454
Location (UCSC)	Chr X: 111.77 – 112.08 Mb	Chr X: 144.38 – 144.69 Mb
PubMed search	[1]	[2]

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene. TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.

Function

TrpC5 is one of the seven mammalian TRPC (transient receptor potential channel) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na⁺–H⁺ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).

TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity and neurological behavior.

Activation

Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin. This channel has also been found to be involved in the action of anaesthetics such as chloroform, halothane and propofol.

Interactions

TRPC5 has been shown to interact with STMN3, TRPC1, and TRPC4.

See also

• TRPC

External links

• TRPC5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.