CACNA2D2

Calcium channel, voltage-dependent, alpha 2/delta subunit 2
Identifiers
Symbols	CACNA2D2 ; CACNA2D
External IDs	OMIM: 607082 MGI: 1929813 HomoloGene: 4400 ChEMBL: 3896 GeneCards: CACNA2D2 Gene
Gene ontology Molecular function • voltage-gated calcium channel activity • calcium channel regulator activity • metal ion binding Cellular component • plasma membrane • voltage-gated calcium channel complex Biological process • energy reserve metabolic process • neuromuscular junction development • regulation of ion transmembrane transport • regulation of multicellular organism growth • small molecule metabolic process • positive regulation of organ growth • muscle fiber development • regulation of insulin secretion • regulation of calcium ion transport • rhythmic synaptic transmission • calcium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CACNA2D2 204811 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9254	56808
Ensembl	ENSG00000007402	ENSMUSG00000010066
UniProt	Q9NY47	Q6PHS9
RefSeq (mRNA)	NM_001005505	NM_001174047
RefSeq (protein)	NP_001005505	NP_001167518
Location (UCSC)	Chr 3: 50.36 – 50.5 Mb	Chr 9: 107.4 – 107.53 Mb
PubMed search	[1]	[2]

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

See also

• Voltage-dependent calcium channel

External links

• CACNA2D2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.