Porfimer sodium
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| Clinical data | |
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| AHFS/Drugs.com | Consumer Drug Information |
| Licence data | EMA:Link, US FDA:link |
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| Routes of administration |
Intravenous |
| Pharmacokinetic data | |
| Bioavailability | NA |
| Protein binding | ~90% |
| Biological half-life | 21.5 days (mean) |
| Excretion | Fecal |
| Identifiers | |
| CAS Number | 97067-70-4  Template:CAS |
| ATC code | L01XD01 (WHO) |
| PubChem | CID: 57166 |
| DrugBank | DB00707 |
| ChemSpider | 10482283  |
| UNII | Y3834SIK5F |
| ChEMBL | CHEMBL1201707 |
| Chemical data | |
| Formula | C68H74N8O11 (for n=0) |
| Molecular mass | 1179.36 g/mol (for n=0) |
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Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.
Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units.[1] In practice, a red light source emitting at 630 nm is used to excite the Porfimer oligomers.[2]
Porfimer is Haematoporphyrin Derivative (HpD) (See PDT).
Approvals and indications
It was approved in Canada in 1993 for the treatment of bladder cancer.[2] It was approved in Japan in 1994 (for early stage lung cancer?).[2] It was approved by the U.S. FDA in December 1995 for esophageal cancer, and in 1998, it was approved for the treatment of early non-small cell lung cancer.[2]
In August 2003 the FDA approved its use for Barrett's esophagus.[3]
References
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