Nepafenac

Nepafenac

File:Nepafenac-2D-skeletal.svg
Systematic (IUPAC) name
2-amino-3-benzoylbenzeneacetamide
Clinical data
Trade names	Nevanac
AHFS/Drugs.com	monograph
MedlinePlus	a606007
Pregnancy category	US: C (Risk not ruled out)
Legal status	US: ℞-only
Routes of administration	Ophthalmic
Identifiers
ATC code	S01BC10 (WHO)
PubChem	CID: 151075
IUPHAR/BPS	7564
DrugBank	DB06802 Y
ChemSpider	133160 Y
UNII	0J9L7J6V8C Y
KEGG	D05143 Y
ChEBI	CHEBI:75922 N
ChEMBL	CHEMBL1021 Y
Chemical data
Formula	C15H14N2O2
Molecular mass	254.28 g/mol
SMILES O=C(c1cccc(c1N)CC(=O)N)c2ccccc2
InChI InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18) Y Key:QEFAQIPZVLVERP-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop 0.1% solution. Nepafenac is manufactured by Alcon and sold under the trade name Nevanac. It is used to treat pain and inflammation associated with cataract surgery.

The usual dose is one drop, thrice a day, in each affected eye beginning one day prior to cataract surgery, continued on the day of surgery and through the first two weeks of the postoperative period.

Nepafenac is a prodrug of amfenac, an inhibitor of COX-1 and COX-2 activity. Its side effects may include decreased visual acuity, a feeling that something is in the eye, increased eye pressure or a sticky sensation, as well as other effects.

Brand names of Nepafenac include Ilevro and Nevanac.